The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

Garlic has long been considered as a natural remedy against a range of human illnesses,
including various bacterial, viral and fungal infections. This kind of antibiotic activity of garlic …

ABSTRACT A simple disk diffusion test was constructed for detection of IMP-1-type metallo-β-
lactamase-producing gram-negative bacteria. Two Kirby-Bauer disks containing ceftazidime …

Metallo β-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the
hydrolysis of β-lactam antibiotics. This relatively new form of resistance is spreading …

IMP-1 metallo-β-lactamase (class B) is a plasmid-borne zinc metalloenzyme that efficiently
hydrolyzes β-lactam antibiotics, including carbapenems, rendering them ineffective …

The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-
negative bacteria is a serious concern to public health. MBLs are compromising the …

The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …

Resistance to β-lactam antibiotics mediated by metallo-β-lactamases is an increasingly
worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we …

Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of
IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship …

Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …