[HTML][HTML] Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders

DE Astle, J Holmes, R Kievit… - Journal of Child …, 2022 - Wiley Online Library
Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental
disorders and to guide intervention decisions. These criteria also provide the organising …

Ancestry-inclusive dog genomics challenges popular breed stereotypes

K Morrill, J Hekman, X Li, J McClure, B Logan… - Science, 2022 - science.org
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

The genetics of epilepsy

P Perucca, M Bahlo, SF Berkovic - Annual review of genomics …, 2020 - annualreviews.org
Epilepsy encompasses a group of heterogeneous brain diseases that affect more than 50
million people worldwide. Epilepsy may have discernible structural, infectious, metabolic …

Upper cortical layer–driven network impairment in schizophrenia

MY Batiuk, T Tyler, K Dragicevic, S Mei, R Rydbirk… - Science …, 2022 - science.org
Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …

[HTML][HTML] Genetic variation, brain, and intelligence differences

IJ Deary, SR Cox, WD Hill - Molecular psychiatry, 2022 - nature.com
Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …

[HTML][HTML] Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

WD Hill, NM Davies, SJ Ritchie, NG Skene… - Nature …, 2019 - nature.com
Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing)
multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 …

[HTML][HTML] The enigmatic fetal subplate compartment forms an early tangential cortical nexus and provides the framework for construction of cortical connectivity

I Kostović - Progress in neurobiology, 2020 - Elsevier
The most prominent transient compartment of the primate fetal cortex is the deep, cell-
sparse, synapse-containing subplate compartment (SPC). The developmental role of the …

Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS

WJ Peyrot, AL Price - Nature genetics, 2021 - nature.com
Psychiatric disorders are highly genetically correlated, but little research has been
conducted on the genetic differences between disorders. We developed a new method …

[HTML][HTML] Does better education mitigate risky health behavior? A mendelian randomization study

J Viinikainen, A Bryson, P Böckerman, JT Kari… - Economics & Human …, 2022 - Elsevier
Education and risky health behaviors are strongly negatively correlated. Education may
affect health behaviors by enabling healthier choices through higher disposable income …