Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
[HTML][HTML] Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
[HTML][HTML] A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
Epigenetic roles in clonal hematopoiesis and aging kidney-related chronic kidney disease
Y Ogura, I Mimura - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Accumulation of somatic hematopoietic stem cell mutations with aging has been revealed by
the recent genome-wide analysis. Clonal expansion, known as clonal hematopoiesis of …
the recent genome-wide analysis. Clonal expansion, known as clonal hematopoiesis of …
Tet2-and Tet3-mediated cytosine hydroxymethylation in Six2 progenitor cells in mice is critical for nephron progenitor differentiation and nephron endowment
Background Nephron endowment is a key determinant of hypertension and renal disease in
later life. Epigenetic changes have been proposed to mediate fetal programming and …
later life. Epigenetic changes have been proposed to mediate fetal programming and …
[HTML][HTML] Identification of a novel 5-methylcytosine-related signature for prognostic prediction of kidney renal papillary cell carcinoma and a Putative target for drug …
Z Zhang, C Cao, CL Zhou, X Li, C Miao, L Shen… - Translational …, 2023 - Elsevier
Background Many studies have demonstrated the crucial roles of 5-methylcytosine (m5C)
RNA methylation in cancer pathogenesis. Methods Two datasets, including TCGA-KIRP and …
RNA methylation in cancer pathogenesis. Methods Two datasets, including TCGA-KIRP and …
Sex differences in fetal kidney reprogramming: the case in the renin-angiotensin system
M Pérez-Coria, GE Vázquez-Rivera… - Pediatric …, 2024 - Springer
During the early stages of the development of the living multiorgan systems, genome
modifications other than sequence variation occur that guide cell differentiation and …
modifications other than sequence variation occur that guide cell differentiation and …
Lysine-specific demethylase 1 as a corepressor of mineralocorticoid receptor
N Kohata, I Kurihara, K Yokota, S Kobayashi… - Hypertension …, 2022 - nature.com
Mineralocorticoid receptor (MR) and its ligand aldosterone play a central role in controlling
blood pressure by promoting sodium reabsorption in the kidney. Coregulators are recruited …
blood pressure by promoting sodium reabsorption in the kidney. Coregulators are recruited …
[HTML][HTML] Bayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogs
F Lingaas, K Tengvall, JH Jansen, L Pelander… - PLoS …, 2023 - journals.plos.org
Chronic kidney disease (CKD) affects 10% of the human population, with only a small
fraction genetically defined. CKD is also common in dogs and has been diagnosed in nearly …
fraction genetically defined. CKD is also common in dogs and has been diagnosed in nearly …
[HTML][HTML] Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis
X Xiao, E Huo, C Guo, X Zhou, X Hu, C Dong… - Research …, 2023 - ncbi.nlm.nih.gov
Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in
renal fibrosis. Here, we report the regulation of microRNA-219a-2 (mir-219a-2) by DNA …
renal fibrosis. Here, we report the regulation of microRNA-219a-2 (mir-219a-2) by DNA …