CYP3A4 is the most important drug metabolizing enzyme in adult humans because of its
prominent expression in liver and gut and because of its broad substrate specificity, which …

Cytochrome P450 3A4 (CYP3A4), one of the most important members of the cytochrome
P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs. As it catalyzes …

Adverse events, response failures and medication non-compliance are common in patients
receiving medications for the treatment of mental illnesses. A systematic literature review …

Aim: To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han
Chinese population. Materials & methods: The promoter and exons of CYP3A4 gene in …

Background Adequate opioid prescribing is critical for therapeutic success of pain
management. Despite the widespread use of opioids, optimized opioid therapy remains …

Background Genetic variability may influence methadone metabolism, dose requirements,
and risk of relapse. Objectives To determine whether the CYP2B6* 6 or ABCB1 (rs1045642) …

As a chronic brain disease, epilepsy affects~ 50 million people worldwide. The traditional
antiepileptic drugs (AEDs) are widely applied but showing various problems. Although the …

The epidemic use of illicit drugs has led to an increasing number of patients with drug
addiction and dependence presenting for perioperative care. There are a wide variety of …

Methadone maintenance treatment (MMT) is commonly used for controlling opioid
dependence, preventing withdrawal symptoms, and improving the quality of life of heroin …

Cannabis and related compounds have created significant research interest as a promising
therapy in many disorders. However, the individual therapeutic effects of cannabinoids and …