Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
Development of a clinical polygenic risk score assay and reporting workflow
Implementation of polygenic risk scores (PRS) may improve disease prevention and
management but poses several challenges: the construction of clinically valid assays …
management but poses several challenges: the construction of clinically valid assays …
The genetics of type 2 diabetes in youth: Where we are and the road ahead
S Srinivasan, J Todd - The Journal of pediatrics, 2022 - jpeds.com
The incidence of type 2 diabetes (T2D) is on the rise in youth in the US 1, 2 and worldwide. 3
T2D is characterized by hyperglycemia from a combination of insulin resistance and relative …
T2D is characterized by hyperglycemia from a combination of insulin resistance and relative …
Multi‐Omics Studies in Historically Excluded Populations: The Road to Equity
Over the past few decades, genomewide association studies (GWASs) have identified the
specific genetics variants contributing to many complex diseases by testing millions of …
specific genetics variants contributing to many complex diseases by testing millions of …