Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …

Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …

In recent work, Wang et al introduced the “Sum of Single Effects”(SuSiE) model, and showed
that it provides a simple and efficient approach to fine-mapping genetic variants from …

Fine-mapping is commonly used to identify putative causal variants at genome-wide
significant loci. Here we propose a Bayesian model for fine-mapping that has several …

The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and
its subfields differ in architecture and function. Genome-wide association studies on …

Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic
association studies, LD is often modeled using large correlation matrices, but this approach …

Fine-mapping aims to identify causal genetic variants for phenotypes. Bayesian fine-
mapping algorithms (for example, SuSiE, FINEMAP, ABF and COJO-ABF) are widely used …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …