Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …

More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

The interaction between drugs and various transporters is one of the decisive factors that
affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter …

The balance of cisplatin uptake and efflux, mediated mainly by organic cation transporter 2
(OCT2) and multidrug and toxin extrusion 1 (MATE1), respectively, determines the renal …

Purpose The organic cation transporters (OCTs) and multidrug and toxin extrusions (MATEs)
together are regarded as an organic cation transport system critical to the disposition and …

Nephrotoxicity is a major adverse reaction of cisplatin-based chemotherapy. Organic cation
transporter 2 (OCT2) which is located on the basement membrane of human proximal renal …

Cisplatin (CDDP) is a well-known chemotherapeutic drug approved for various cancers.
However, CDDP accumulates in the inner ear cochlea via organic cation transporter 2 …

One of the major side effects of cyclophosphamide (CPX)—an alkylating anticancer drug
that is still clinically used—is urotoxicity with hemorrhagic cystitis. The present study was …

Introduction Membrane transporters are now widely recognized for their role in the
absorption, distribution, clearance, and elimination of drugs. The organic cation transporters …