[HTML][HTML] Kidney fibrosis: from mechanisms to therapeutic medicines
R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
Immunology of human fibrosis
M Bhattacharya, P Ramachandran - Nature Immunology, 2023 - nature.com
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
[HTML][HTML] NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
Our understanding of how global changes in cellular metabolism contribute to human kidney
disease remains incompletely understood. Here we show that nicotinamide adenine …
disease remains incompletely understood. Here we show that nicotinamide adenine …
Unified mouse and human kidney single-cell expression atlas reveal commonalities and differences in disease states
Background Mouse models have been widely used to understand kidney disease
pathomechanisms and play an important role in drug discovery. However, these models …
pathomechanisms and play an important role in drug discovery. However, these models …
[PDF][PDF] Treatment effects of soluble guanylate cyclase modulation on diabetic kidney disease at single-cell resolution
Diabetic kidney disease (DKD) is the most common cause of renal failure. Therapeutics
development is hampered by our incomplete understanding of animal models on a cellular …
development is hampered by our incomplete understanding of animal models on a cellular …
[HTML][HTML] Basophils beyond allergic and parasitic diseases
Basophils bind IgE via FcεRI-αβγ 2, which they uniquely share only with mast cells. In doing
so, they can rapidly release mediators that are hallmark of allergic disease. This …
so, they can rapidly release mediators that are hallmark of allergic disease. This …
Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression
Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …
yet the spatial and molecular principles of kidney health and disease remain inadequately …
[HTML][HTML] Molecular pathways that drive diabetic kidney disease
Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …
[HTML][HTML] Identification of endoplasmic reticulum stress-related biomarkers of diabetes nephropathy based on bioinformatics and machine learning
J Su, J Peng, L Wang, H Xie, Y Zhou, H Chen… - Frontiers in …, 2023 - frontiersin.org
Backgrounds Diabetes nephropathy (DN) is a growing public health concern worldwide.
Renal dysfunction impairment in DN is intimately linked to ER stress and its related signaling …
Renal dysfunction impairment in DN is intimately linked to ER stress and its related signaling …
[HTML][HTML] Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists
A Abedini, A Sánchez-Navaro, J Wu… - The Journal of …, 2024 - Am Soc Clin Investig
Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …
study, we used single-cell expression and chromatin accessibility tools to characterize the …