Introduction Chronic kidney disease of uncertain etiology (CKDu) is an incompletely defined
phenotype of CKD affecting young individuals mostly in agricultural communities in Central …

Background: In autosomal dominant polycystic kidney disease (ADPKD) there is an unmet
need for early markers of rapid disease progression to facilitate counseling and selection for …

There has been limited research on assessing metalloproteinases (MMPs) 1, 2, and 7, as
well as their tissue inhibitors (TIMPs) 1, 2, 3, and 4 in the context of polytrauma. These …

ABSTRACT Matrix metalloproteinase 7 (MMP-7) is a secreted endopeptidase involved in the
degradation of extracellular matrix components and the activation of cytokines and growth …

Background Kidney fibrosis is the common final pathway of virtually all advanced forms of
chronic kidney disease (CKD) including diabetic nephropathy (DN), IgA nephropathy (IgAN) …

In the United States, kidney diseases are a leading cause of death. According to the Center
for Disease Control and Prevention, approximately 37 million US adults are estimated to …

The invasion and metastasis of gastric cancer pose frequent clinical challenges following
standard treatment. Investigating the molecular mechanisms underpinning gastric cancer …

Background: Chronic kidney disease (CKD) is a global health concern with significant
implications for public health and mortality rates, projected to become the fifth leading cause …