Improving reporting standards for polygenic scores in risk prediction studies
H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples
Objective: Interest in candidate gene and candidate gene-by-environment interaction
hypotheses regarding major depressive disorder remains strong despite controversy …
hypotheses regarding major depressive disorder remains strong despite controversy …
Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK Biobank
MC Pitharouli, SP Hagenaars… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: The authors investigated the pathways (genetic, environmental, lifestyle, medical)
leading to inflammation in major depressive disorder using C-reactive protein (CRP) …
leading to inflammation in major depressive disorder using C-reactive protein (CRP) …
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems.
However, the extent to which adverse childhood experiences (ACEs) cause mental health …
However, the extent to which adverse childhood experiences (ACEs) cause mental health …
The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls
JRI Coleman, HA Gaspar, J Bryois, EM Byrne… - Biological …, 2020 - Elsevier
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe …
affect 10% to 20% of the population. They range from brief, mild episodes to severe …
Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics
J Ding, M Blencowe, T Nghiem, S Ha… - Nucleic Acids …, 2021 - academic.oup.com
The Mergeomics web server is a flexible online tool for multi-omics data integration to derive
biological pathways, networks, and key drivers important to disease pathogenesis and is …
biological pathways, networks, and key drivers important to disease pathogenesis and is …
Psilocybin and MDMA for the treatment of trauma-related psychopathology
CIV Bird, NL Modlin, JJH Rucker - International Review of …, 2021 - Taylor & Francis
This review examines the role of trauma in psychiatric morbidity and analogous
psychoneurobiological changes. Trauma is a necessary criterion for Post-Traumatic Stress …
psychoneurobiological changes. Trauma is a necessary criterion for Post-Traumatic Stress …
Risk in relatives, heritability, SNP-based heritability, and genetic correlations in psychiatric disorders: a review
The genetic contribution to psychiatric disorders is observed through the increased rates of
disorders in the relatives of those diagnosed with disorders. These increased rates are …
disorders in the relatives of those diagnosed with disorders. These increased rates are …
Mental health and music engagement: review, framework, and guidelines for future studies
Is engaging with music good for your mental health? This question has long been the topic
of empirical clinical and nonclinical investigations, with studies indicating positive …
of empirical clinical and nonclinical investigations, with studies indicating positive …