A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
ALDH2 variance in disease and populations
CH Chen, BR Kraemer… - Disease Models & …, 2022 - journals.biologists.com
The ALDH2* 2 missense variant that commonly causes alcohol flushing reactions is the
single genetic polymorphism associated with the largest number of traits in humans. The …
single genetic polymorphism associated with the largest number of traits in humans. The …
[HTML][HTML] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
R Edahiro, Y Shirai, Y Takeshima, S Sakakibara… - Nature …, 2023 - nature.com
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
[HTML][HTML] DOCK2 is involved in the host genetics and biology of severe COVID-19
H Namkoong, R Edahiro, T Takano, H Nishihara… - Nature, 2022 - nature.com
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge,,,–
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …
Progress in genetics of type 2 diabetes and diabetic complications
N Shojima, T Yamauchi - Journal of Diabetes Investigation, 2023 - Wiley Online Library
Type 2 diabetes results from a complex interaction between genetic and environmental
factors. Precision medicine for type 2 diabetes using genetic data is expected to predict the …
factors. Precision medicine for type 2 diabetes using genetic data is expected to predict the …
Chromosomal alterations among age-related haematopoietic clones in Japan
The extent to which the biology of oncogenesis and ageing are shaped by factors that
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …
[HTML][HTML] Reconstruction of the personal information from human genome reads in gut metagenome sequencing data
Y Tomofuji, K Sonehara, T Kishikawa, Y Maeda… - Nature …, 2023 - nature.com
Human DNA present in faecal samples can result in a small number of human reads in gut
shotgun metagenomic sequencing data. However, it is presently unclear how much …
shotgun metagenomic sequencing data. However, it is presently unclear how much …
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population
To understand the genetics of type 2 diabetes in people of Japanese ancestry, we
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …