Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …

Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral …

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …

Over the past decade, statistical methods have been developed to estimate single
nucleotide polymorphism (SNP) heritability, which measures the proportion of phenotypic …

The problem of missing heritability, that is to say the gap between heritability estimates from
genotype data and heritability estimates from twin data, has been a source of debate for …

There is currently much debate regarding the best model for how heritability varies across
the genome. The authors of GCTA recommend the GCTA-LDMS-I model, the authors of LD …

Many traits are subject to assortative mating, with recent molecular genetic findings
confirming longstanding theoretical predictions that assortative mating induces long range …

Genetically informed, deep-phenotyped biobanks are an important research resource and it
is imperative that the most powerful, versatile, and efficient analysis approaches are used …

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

Identification of gene-by-environment interactions (GxE) is crucial to understand the
interplay of environmental effects on complex traits. However, current methods evaluating …