Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …

Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …

Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …

Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …

Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …

Idiopathic pulmonary fibrosis (IPF) is a chronic, rare progressive lung disease, characterized
by lung scarring and the irreversible loss of lung function. Two anti-fibrotic drugs, nintedanib …

Recent advances in the genetics of idiopathic pulmonary fibr... : Current Opinion in Pulmonary
Medicine Recent advances in the genetics of idiopathic pulmonary fibrosis : Current Opinion …