Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …

Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce a
switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes …

We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …

UK Biobank is a major prospective epidemiological study, including multimodal brain
imaging, genetics and ongoing health outcomes. Previously, we published genome-wide …

We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …

Abstract Principal Component Analysis (PCA) is a multivariate analysis that reduces the
complexity of datasets while preserving data covariance. The outcome can be visualized on …

Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

Metabolic diseases are the most common and rapidly growing health issues worldwide. The
massive population-based human genetics is crucial for the precise prevention and …

Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …