Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …
Personalized medicine in psychiatry: problems and promises
U Ozomaro, C Wahlestedt, CB Nemeroff - BMC medicine, 2013 - Springer
The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …
physiologic characteristics play a significant role in both disease vulnerability and in …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
Biological insights from 108 schizophrenia-associated genetic loci
C Pantelis, GN Papadimitriou, S Papiol… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
De novo mutations in schizophrenia implicate synaptic networks
M Fromer, AJ Pocklington, DH Kavanagh, HJ Williams… - Nature, 2014 - nature.com
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate
Several lines of evidence suggest that genome-wide association studies (GWAS) have the
potential to explain more of the “missing heritability” of common complex phenotypes …
potential to explain more of the “missing heritability” of common complex phenotypes …
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia …
ML Hamshere, JTR Walters, R Smith, AL Richards… - Molecular …, 2013 - nature.com
Abstract The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC)
highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for …
highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for …
Sharing and specificity of co-expression networks across 35 human tissues
To understand the regulation of tissue-specific gene expression, the GTEx Consortium
generated RNA-seq expression data for more than thirty distinct human tissues. This data …
generated RNA-seq expression data for more than thirty distinct human tissues. This data …
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci
Genetic and environmental components as well as their interaction contribute to the risk of
schizophrenia, making it highly relevant to include environmental factors in genetic studies …
schizophrenia, making it highly relevant to include environmental factors in genetic studies …