The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has affected countries across the world. While the …

Abstract To date, SARS-CoV-2 (the virus that causes COVID-19) has spread to almost every
region of the world, infecting millions and resulting in the deaths of hundreds of thousands of …

The poor transferability of genetic risk scores (GRSs) derived from European ancestry data
in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived …

Background Central centrifugal cicatricial alopecia (CCCA) is the most common form of
scarring alopecia among women of African ancestry. The disease is occasionally observed …

Populations residing for millennia on the high-altitude plateaus of the world started natural
experiments that we can evaluate to address questions about the processes of evolution …

Our understanding of human evolution has improved rapidly over recent decades, facilitated
by large‐scale cataloguing of genomic variability amongst both modern and archaic …

To embrace the prospects of accurately diagnosing thousands of monogenic conditions,
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …

Historically marginalized racial and ethnic groups and Indigenous peoples are burdened by
significant health inequities that are compounded by their underrepresentation in genetic …

Genetic models for cancer have been evaluated using almost exclusively European data,
which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated …

TP53 is crucial for maintaining genome stability and preventing oncogenesis. Germline
pathogenic variation in TP53 damages its function, causing genome instability and …