Genetics of bipolar disorder

N Craddock, P Sklar - The Lancet, 2013 - thelancet.com
Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …

Candidate gene–environment interaction research: Reflections and recommendations

DM Dick, A Agrawal, MC Keller… - Perspectives on …, 2015 - journals.sagepub.com
Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …

Identification of common genetic risk variants for autism spectrum disorder

J Grove, S Ripke, TD Als, M Mattheisen, RK Walters… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses

B Bortolato, KW Miskowiak, CA Köhler… - Neuropsychiatric …, 2015 - Taylor & Francis
Cognitive impairment is a core feature of schizophrenia (SZ) and bipolar disorder (BD). A
neurocognitive profile characterized by widespread cognitive deficits across multiple …

16p11. 2 copy number variations and neurodevelopmental disorders

B Rein, Z Yan - Trends in neurosciences, 2020 - cell.com
Copy number variations (CNVs) of the human 16p11. 2 genetic locus are associated with a
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …

Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder

AG Cardno, MJ Owen - Schizophrenia bulletin, 2014 - academic.oup.com
There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …

Vascular contributions to 16p11. 2 deletion autism syndrome modeled in mice

J Ouellette, X Toussay, CH Comin, LF Costa… - Nature …, 2020 - nature.com
While the neuronal underpinnings of autism spectrum disorder (ASD) are being unraveled,
vascular contributions to ASD remain elusive. Here, we investigated postnatal …

Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders

YS Kim, BL Leventhal - Biological psychiatry, 2015 - Elsevier
Understanding the pathogenesis of neurodevelopmental disorders has proven to be
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …

[HTML][HTML] Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

M Richter, N Murtaza, R Scharrenberg, SH White… - Molecular …, 2019 - nature.com
Atypical brain connectivity is a major contributor to the pathophysiology of
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …

Kctd13 deletion reduces synaptic transmission via increased RhoA

CO Escamilla, I Filonova, AK Walker, ZX Xuan… - Nature, 2017 - nature.com
Copy-number variants of chromosome 16 region 16p11. 2 are linked to neuropsychiatric
disorders,,,,, and are among the most prevalent in autism spectrum disorders,,. Of many …