The MR-Base platform supports systematic causal inference across the human phenome
Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
M Sohail, RM Maier, A Ganna, A Bloemendal… - Elife, 2019 - elifesciences.org
Genetic predictions of height differ among human populations and these differences have
been interpreted as evidence of polygenic adaptation. These differences were first detected …
been interpreted as evidence of polygenic adaptation. These differences were first detected …
[HTML][HTML] A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
Background Multimorbidities greatly increase the global health burdens, but the landscapes
of their genetic risks have not been systematically investigated. Methods We used the …
of their genetic risks have not been systematically investigated. Methods We used the …
Reduced signal for polygenic adaptation of height in UK Biobank
Several recent papers have reported strong signals of selection on European polygenic
height scores. These analyses used height effect estimates from the GIANT consortium and …
height scores. These analyses used height effect estimates from the GIANT consortium and …
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …
Rare penetrant mutations confer severe risk of common diseases
We examined 454,712 exomes for genes associated with a wide spectrum of complex traits
and common diseases and observed that rare, penetrant mutations in genes implicated by …
and common diseases and observed that rare, penetrant mutations in genes implicated by …
Genetic correlates of social stratification in Great Britain
A Abdellaoui, D Hugh-Jones, L Yengo… - Nature human …, 2019 - nature.com
Human DNA polymorphisms vary across geographic regions, with the most commonly
observed variation reflecting distant ancestry differences. Here we investigate the …
observed variation reflecting distant ancestry differences. Here we investigate the …
[HTML][HTML] Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects
G Qi, N Chatterjee - Nature communications, 2019 - nature.com
Mendelian randomization (MR) has emerged as a major tool for the investigation of causal
relationship among traits, utilizing results from large-scale genome-wide association studies …
relationship among traits, utilizing results from large-scale genome-wide association studies …
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
The age of large-scale genome-wide association studies (GWAS) has provided us with an
unprecedented opportunity to evaluate the genetic liability of complex disease using …
unprecedented opportunity to evaluate the genetic liability of complex disease using …
Use of genetic variants related to antihypertensive drugs to inform on efficacy and side effects
Background: Drug effects can be investigated through natural variation in the genes for their
protein targets. The present study aimed to use this approach to explore the potential side …
protein targets. The present study aimed to use this approach to explore the potential side …