Prostate cancer is a paradigm tumor model for heterogeneity in almost every sense. Its clinical, spatial, and morphological heterogeneity divided by the high-level molecular …
MM Pomerantz, X Qiu, Y Zhu, DY Takeda, W Pan… - Nature …, 2020 - nature.com
Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …
Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that …
Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
Transcriptome-wide association studies using predicted expression have identified thousands of genes whose locally regulated expression is associated with complex traits …
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely …
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary …
G Di Pietro, G Chornokur, NB Kumar… - International …, 2016 - ncbi.nlm.nih.gov
Abstract Disparities between African American and Caucasian men in prostate cancer (PCa) diagnosis and treatment in the United States have been well established, with significant …
SH Tan, G Petrovics, S Srivastava - International journal of molecular …, 2018 - mdpi.com
Prostate cancer (CaP) is the most commonly diagnosed non-cutaneous cancer and the second leading cause of male cancer deaths in the United States. Among African American …