The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications

Z Hu, D Ma - Cancer medicine, 2018 - Wiley Online Library
Cervical cancer is the third most common cancer in women worldwide, with concepts and
knowledge about its prevention and treatment evolving rapidly. Human papillomavirus …

Genomic characterization of viral integration sites in HPV‐related cancers

C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …

[HTML][HTML] Pathophysiology of ocular surface squamous neoplasia

S Gichuhi, S Ohnuma, MS Sagoo, MJ Burton - Experimental eye research, 2014 - Elsevier
The incidence of ocular surface squamous neoplasia (OSSN) is strongly associated with
solar ultraviolet (UV) radiation, HIV and human papilloma virus (HPV). Africa has the highest …

Viral load, gene expression and mapping of viral integration sites in HPV16‐associated HNSCC cell lines

NC Olthof, CU Huebbers, J Kolligs… - … journal of cancer, 2015 - Wiley Online Library
HPV‐related HNSCC generally have a better prognosis than HPV‐negative HNSCC.
However, a subgroup of HPV‐positive tumors with poor prognosis has been recognized …

[HTML][HTML] Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene …

NC Olthof, EJM Speel, J Kolligs, A Haesevoets… - PloS one, 2014 - journals.plos.org
Infection with high-risk human papillomavirus (HPV) type 16 is an independent risk factor for
the development of oropharyngeal squamous cell carcinomas (OSCC). However, it is …

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells

BS Sørensen, M Busk, N Olthof, EJ Speel… - Radiotherapy and …, 2013 - Elsevier
Background and purpose HPV associated Head and Neck Squamous Cell Carcinoma
(HNSCC) represents a distinct subgroup of HNSCC characterized by a favorable prognosis …

[HTML][HTML] Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome

MK Jang, K Shen, AA McBride - PLoS pathogens, 2014 - journals.plos.org
It has long been recognized that oncogenic viruses often integrate close to common fragile
sites. The papillomavirus E2 protein, in complex with BRD4, tethers the viral genome to host …

Molecular approaches for HPV genotyping and HPV-DNA physical status

D Tsakogiannis, C Gartzonika… - Expert reviews in …, 2017 - cambridge.org
Persistent infection with high-risk human papillomavirus (HPV) genotypes is the leading
cause of cervical cancer development. To this end several studies have focused on …

Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms

A Scheel, GC Lin, JB McHugh… - International forum of …, 2015 - Wiley Online Library
Background The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs)
is controversial. Determining the prevalence of HPV infection and its impact on the …

[HTML][HTML] The analysis of HPV integration sites based on nanopore sequencing and the profiling changes along the course of photodynamic therapy

X Li, X Wei, X Liu, N Wang, F Xu, X Liu, Y Li, Y Zhou… - BMC cancer, 2023 - Springer
Objective To detect the HPV genotype and integration sites in patients with high-risk HPV
infection at different stages of photodynamic therapy using nanopore technology and to …