[HTML][HTML] Multi-omics approaches to disease
High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …
genotyping arrays enabled large-scale genome-wide association studies and methods for …
Vitamin B12, folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation
DS Froese, B Fowler… - Journal of inherited …, 2019 - Wiley Online Library
Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
Single-cell DNA methylome sequencing of human preimplantation embryos
DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …
development,–. Although the DNA methylome of early human embryos has been analyzed …
[HTML][HTML] Profiling genome-wide DNA methylation
DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …
gene expression and therefore a broad range of biological processes and diseases. DNA …
[HTML][HTML] Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment
Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …
as a type of molecular clock. This clock can be hastened by conditions that decrease …
[HTML][HTML] A multi-tissue full lifespan epigenetic clock for mice
MJ Thompson, K Chwiałkowska, L Rubbi… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …
Epigenetics in natural animal populations
J Hu, RDH Barrett - Journal of Evolutionary Biology, 2017 - academic.oup.com
Phenotypic plasticity is an important mechanism for populations to buffer themselves from
environmental change. While it has long been appreciated that natural populations possess …
environmental change. While it has long been appreciated that natural populations possess …
CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data
Motivation DNA methylation is important for gene silencing and imprinting in both plants and
animals. Recent advances in bisulfite sequencing allow detection of single nucleotide …
animals. Recent advances in bisulfite sequencing allow detection of single nucleotide …
Species‐wide patterns of DNA methylation variation in Quercus lobata and their association with climate gradients
PF Gugger, S Fitz‐Gibbon, M PellEgrini… - Molecular …, 2016 - Wiley Online Library
DNA methylation in plants affects transposon silencing, transcriptional regulation and thus
phenotypic variation. One unanswered question is whether DNA methylation could be …
phenotypic variation. One unanswered question is whether DNA methylation could be …
[HTML][HTML] The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits
AJ Lusis, MM Seldin, H Allayee, BJ Bennett… - Journal of lipid …, 2016 - ASBMB
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-
characterized inbred strains of mice that can be used to analyze the genetic and …
characterized inbred strains of mice that can be used to analyze the genetic and …