[HTML][HTML] ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
A Buniello, JAL MacArthur, M Cerezo… - Nucleic acids …, 2019 - academic.oup.com
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide
association studies enabling investigations to identify causal variants, understand disease …
association studies enabling investigations to identify causal variants, understand disease …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …
cognitive impairment, which is considered a major determinant of functional outcome …
[HTML][HTML] The emerging neurobiology of bipolar disorder
Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …
[HTML][HTML] Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such …
abundance of shared genetic influences among complex human traits and disorders, such …
Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the …
Schizophrenia is associated with widespread alterations in subcortical brain structure. While
analytic methods have enabled more detailed morphometric characterization, findings are …
analytic methods have enabled more detailed morphometric characterization, findings are …
Genetic association between schizophrenia and cortical brain surface area and thickness
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …
variants, each with a small effect. While cortical differences between patients with …