Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …

ABSTRACT Biopharmaceutics Classification System and Biopharmaceutics Drug
Distribution Classification System are complimentary, not competing, classification systems …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

The economic and health burden caused by adverse drug reactions has increased
dramatically in the last few years. This is likely to be mediated by increasing polypharmacy …

Recently, the US Food and Drug Administration and European Medicines Agency have
issued new guidance for industry on drug interaction studies, which outline comprehensive …

Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …

Elucidation of the rate-determining process in the overall hepatic elimination of drugs is
critical for predicting their intrinsic hepatic clearance and the impact of variation of …