Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …

While many disease-associated variants have been identified through genome-wide
association studies, their downstream molecular consequences remain unclear. To identify …

The age of large-scale genome-wide association studies (GWAS) has provided us with an
unprecedented opportunity to evaluate the genetic liability of complex disease using …

Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …

Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk
syndrome is about 15%− 25%; improvements in risk prediction accuracy would benefit the …

Theme issue: Psoriasis loci. Despite the complex correlation structure across the MHC due
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that
somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) …

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …