Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …

In both humans and mice, repair of acute kidney injury is worse in males than in females.
Here, we provide evidence that this sexual dimorphism results from sex differences in …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …

Homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-
induced acute kidney injury (AKI) are poorly understood. Here, we performed single-cell …

Cell death, particularly that of tubule epithelial cells, contributes critically to the
pathophysiology of kidney disease. A body of evidence accumulated over the past 15 years …

Diseases of the heart and the kidney, including heart failure and chronic kidney disease, can
dramatically impair life expectancy and the quality of life of patients. The heart and kidney …

Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone …

Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence
rate worldwide, is characterized by a rapid deterioration of renal function and further triggers …