Single-cell transcriptomics: a new tool for studying diabetic kidney disease

ZH Mao, ZX Gao, Y Liu, DW Liu, ZS Liu… - Frontiers in Physiology, 2023 - frontiersin.org
The kidney is a complex organ comprising various functional partitions and special cell
types that play important roles in maintaining homeostasis in the body. Diabetic kidney …

[HTML][HTML] New insights into the role of immunity and inflammation in diabetic kidney disease in the omics era

X Hu, S Chen, S Ye, W Chen, Y Zhou - Frontiers in Immunology, 2024 - frontiersin.org
Diabetic kidney disease (DKD) is becoming the leading cause of chronic kidney disease,
especially in the industrialized world. Despite mounting evidence has demonstrated that …

Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA

J Wei, J Zhang, J Wei, M Hu, X Chen, X Qin, J Chen… - Plos one, 2023 - journals.plos.org
Acute kidney injury (AKI) is a serious and frequently observed disease associated with high
morbidity and mortality. Weighted gene co-expression network analysis (WGCNA) is a …

Association of amino acids related to urea cycle with risk of diabetic nephropathy in two independent cross-sectional studies of Chinese adults

P Cao, B Huang, M Hong, Y Jiang, R Cao… - Frontiers in …, 2022 - frontiersin.org
Objective To investigate the association between amino acids related to the urea cycle and
diabetic nephropathy (DN) in two independent cross-sectional studies. Methods We …

Tanshinone IIA is superior to paricalcitol in ameliorating tubulointerstitial fibrosis through regulation of VDR/Wnt/β-catenin pathway in rats with diabetic nephropathy

JY Zeng, Y Wang, FY Hong, M Miao, YY Jiang… - Naunyn-Schmiedeberg's …, 2023 - Springer
Glomerulosclerosis and tubulointerstitial fibrosis (TIF) are closely involved in the
development of diabetic nephropathy (DN). Moreover, the development of TIF is closely …

Metabolic predictors of phenotypic traits can replace and complement measured clinical variables in transcriptome-wide association studies

A Niehues, D Bizzarri, MJT Reinders, PE Slagboom… - bioRxiv, 2022 - biorxiv.org
Transcriptome-wide association studies (TWAS) can provide valuable insights into
biological and disease-underlying mechanisms. For studying clinical effects, availability of …