Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial
effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic …

HMG-CoA reductase inhibitors (statins) are the mainstay in the pharmacologic management
of dyslipidemia. Since they are widely prescribed, their safety remains an issue of concern …

Organic anion transporters (OATs) and organic anion transporter polypeptides (OATPs) are
classified within two SLC superfamilies, namely, the SLC22A superfamily and the SLCO …

Gilbert´ s syndrome, also known as benign hyperbilirubinemia, was described more than
100 years ago. It has usually been considered a physiological abnormality characterized by …

Organic anion transporters (OATs) and organic anion‐transporting polypeptides (OATPs),
encoded by a number of solute carrier (SLC) 22A and SLC organic anion (SLCO) genes …

Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move
across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly …

We report the long-term results of a prospective randomized study on the use of
ursodeoxycholic acid (UDCA) for prevention of hepatic complications after allogeneic stem …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Introduction: Statins are the cornerstone of lipid-lowering therapy to reduce the risk of
coronary heart disease. Rosuvastatin and pitavastatin are the two recently developed statins …