[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
Multiple loci are associated with white blood cell phenotypes
White blood cell (WBC) count is a common clinical measure from complete blood count
assays, and it varies widely among healthy individuals. Total WBC count and its constituent …
assays, and it varies widely among healthy individuals. Total WBC count and its constituent …
Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
KS Lo, JG Wilson, LA Lange, AR Folsom, G Galarneau… - Human genetics, 2011 - Springer
Red blood cell, white blood cell, and platelet measures, including their count, sub-type and
volume, are important diagnostic and prognostic clinical parameters for several human …
volume, are important diagnostic and prognostic clinical parameters for several human …
[PDF][PDF] The allelic landscape of human blood cell trait variation and links to common complex disease
WJ Astle, H Elding, T Jiang, D Allen, D Ruklisa… - Cell, 2016 - cell.com
Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …
causal genes and pathways has proven challenging. We performed a genome-wide …
[PDF][PDF] The polygenic and monogenic basis of blood traits and diseases
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
[PDF][PDF] Systematic functional dissection of common genetic variation affecting red blood cell traits
JC Ulirsch, SK Nandakumar, L Wang, FC Giani… - Cell, 2016 - cell.com
Genome-wide association studies (GWAS) have successfully identified thousands of
associations between common genetic variants and human disease phenotypes, but the …
associations between common genetic variants and human disease phenotypes, but the …
[PDF][PDF] Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program
Summary Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and
non-coding disease-causing variants, has largely been applied to clinical diagnosis of …
non-coding disease-causing variants, has largely been applied to clinical diagnosis of …
Genome-wide association study of hematological and biochemical traits in a Japanese population
We report genome-wide association studies for hematological and biochemical traits from∼
14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 …
14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 …
Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project
Blood group genotyping has recently developed into a clinical tool to improve compatibility
of blood transfusions and management of pregnancies. Next-generation sequencing (NGS) …
of blood transfusions and management of pregnancies. Next-generation sequencing (NGS) …
Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations
YR Li, BJ Keating - Genome medicine, 2014 - Springer
Genome-wide association studies (GWASs) are the method most often used by geneticists
to interrogate the human genome, and they provide a cost-effective way to identify the …
to interrogate the human genome, and they provide a cost-effective way to identify the …