The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …

The kidneys integrate information from continuous systemic processes related to the
absorption, distribution, metabolism and excretion (ADME) of metabolites. To identify …

We present a genome-wide association study of metabolic traits in human urine, designed to
investigate the detoxification capacity of the human body. Using NMR spectroscopy, we …

Background The kidneys have a central role in the generation, turnover, transport, and
excretion of metabolites, and these functions can be altered in CKD. Genetic studies of …

Genome-wide association studies with metabolic traits (mGWAS) uncovered many genetic
variants that influence human metabolism. These genetically influenced metabotypes (GIMs) …

Genome-wide association scans with high-throughput metabolic profiling provide
unprecedented insights into how genetic variation influences metabolism and complex …

Metabolic phenotypes are the products of interactions among a variety of factors—dietary,
other lifestyle/environmental, gut microbial and genetic,,. We use a large-scale exploratory …

Metabolite levels in urine may provide insights into genetic mechanisms shaping their
related pathways. We therefore investigate the cumulative contribution of rare, exonic …

Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23
and 19q13 associated with serum creatinine, a marker of kidney function (P= 10− 10 to 10 …

The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …