A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
[PDF][PDF] Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
Genome-wide association studies (GWASs) have successfully identified 145 genomic
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …
Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling
D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
[PDF][PDF] Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
The hippocampus formation, although prominently implicated in schizophrenia
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …
[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
[HTML][HTML] A genome-wide association study suggests novel loci associated with a schizophrenia-related brain-based phenotype
Patients with schizophrenia and their siblings typically show subtle changes of brain
structures, such as a reduction of hippocampal volume. Hippocampal volume is heritable …
structures, such as a reduction of hippocampal volume. Hippocampal volume is heritable …
Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes
Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene
prioritization and pathway analysis have focused on a priori hypotheses and thus may have …
prioritization and pathway analysis have focused on a priori hypotheses and thus may have …
[HTML][HTML] Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia
Hundreds of genomic loci have been identified with the recent advances of schizophrenia in
genome-wide association studies (GWAS) and sequencing studies. However, the functional …
genome-wide association studies (GWAS) and sequencing studies. However, the functional …