Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level,
and the aim is to use them as biomarkers of disease and poor outcomes in real-world …

As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve
health outcomes, knowing the probabilistic susceptibility of developing a disorder could …

Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …

Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a …

Major psychiatric disorders are heritable but they are genetically complex. This means that,
with certain exceptions, single gene markers will not be helpful for diagnosis. However, we …

Studying the phenotypic manifestations of increased genetic liability for schizophrenia can
increase our understanding of this disorder. Specifically, information from alleles identified in …

Abstract Background Polygenic scores (PGSs), which assess the genetic risk of individuals
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …

Over the last years, the decreased costs and enhanced accessibility to large genome-wide
association studies datasets have laid the foundations for the development of polygenic risk …

Primary prevention in individuals at Clinical High Risk for psychosis (CHR-P) can ameliorate
the course of psychotic disorders. Further advancements of knowledge have been slowed …

Schizophrenia is a serious mental disorder with considerable somatic and psychiatric
morbidity. It is unclear whether comorbid health conditions predominantly arise due to …