Ten challenges for clinical translation in psychiatric genetics

EM Derks, JG Thorp, ZF Gerring - Nature genetics, 2022 - nature.com
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Embracing polygenicity: a review of methods and tools for psychiatric genetics research

RM Maier, PM Visscher, MR Robinson… - Psychological …, 2018 - cambridge.org
The availability of genome-wide genetic data on hundreds of thousands of people has led to
an equally rapid growth in methodologies available to analyse these data. While the …

[HTML][HTML] Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

E Rees, MJ Owen - Genome Medicine, 2020 - Springer
The primary aim of precision medicine is to tailor healthcare more closely to the needs of
individual patients. This requires progress in two areas: the development of more precise …

[HTML][HTML] Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice

JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges

OB Smeland, O Frei, CC Fan, A Shadrin… - Psychiatric …, 2019 - journals.lww.com
Genome-wide association studies have transformed psychiatric genetics and provided novel
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …

Psychiatric genomics: an update and an agenda

PF Sullivan, A Agrawal, CM Bulik… - American Journal of …, 2018 - Am Psychiatric Assoc
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Psychiatric genetics and the structure of psychopathology

JW Smoller, OA Andreassen, HJ Edenberg… - Molecular …, 2019 - nature.com
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

Power in GWAS: lifting the curse of the clinical cut-off

S Van der Sluis, D Posthuma, MG Nivard… - Molecular …, 2013 - nature.com
Although genome-wide association studies (GWAS), in general, facilitated important
discovery of new biological knowledge about diseases, 1--3 identified variants for …

Genome-wide association studies in psychiatry: what have we learned?

AL Collins, PF Sullivan - The British Journal of Psychiatry, 2013 - cambridge.org
Genome-wide association studies (GWAS) have been the focus of considerable effort in
psychiatry. These efforts have markedly increased knowledge of the genetic basis of …