Uromodulin: roles in health and disease

C Schaeffer, O Devuyst… - Annual review of …, 2021 - annualreviews.org
Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Uromodulin: from monogenic to multifactorial diseases

F Scolari, C Izzi, GM Ghiggeri - Nephrology Dialysis …, 2015 - academic.oup.com
Uromodulin, the major protein secreted in normal urine, is exclusively produced in the thick
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …

Uromodulin biology and pathophysiology–an update

P Vyletal, AJ Bleyer, S Kmoch - Kidney and Blood Pressure Research, 2010 - karger.com
Uromodulin (UMOD) is a glycoprotein expressed on the luminal surface of the apical
membrane of renal tubular epithelial cells forming the thick ascending limb of Henle. Here …

Uromodulin: from physiology to rare and complex kidney disorders

O Devuyst, E Olinger, L Rampoldi - Nature Reviews Nephrology, 2017 - nature.com
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

[HTML][HTML] The rediscovery of uromodulin (Tamm–Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease

L Rampoldi, F Scolari, A Amoroso, GM Ghiggeri… - Kidney international, 2011 - Elsevier
Uromodulin (Tamm–Horsfall protein) is the most abundant protein excreted in the urine
under physiological conditions. It is exclusively produced in the kidney and secreted into the …

Determination of uromodulin in human urine: influence of storage and processing

S Youhanna, J Weber, V Beaujean… - Nephrology Dialysis …, 2014 - academic.oup.com
Abstract Background Uromodulin (Tamm–Horsfall protein) is the most abundant protein
excreted in the urine under physiological conditions. It is exclusively produced in the kidney …

A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure

I Bernascone, S Janas, M Ikehata… - Human molecular …, 2010 - academic.oup.com
Uromodulin-associated kidney diseases (UAKD) are autosomal-dominant disorders
characterized by alteration of urinary concentrating ability, tubulo-interstitial fibrosis …

[HTML][HTML] Plasma uromodulin correlates with kidney function and identifies early stages in chronic kidney disease patients

D Steubl, M Block, V Herbst, WA Nockher… - Medicine, 2016 - journals.lww.com
Uromodulin, released from tubular cells of the ascending limb into the blood, may be
associated with kidney function. This work studies the relevance of plasma uromodulin as a …

The value of uromodulin as a new serum marker to predict decline in renal function

A Leiherer, A Muendlein, CH Saely… - Journal of …, 2018 - journals.lww.com
Background: Uromodulin is the most abundant protein in urine. Low uromodulin has been
found associated with diabetes as well as with chronic kidney disease (CKD). Whether it …

Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis

M Olden, T Corre, C Hayward, D Toniolo… - Journal of the …, 2014 - journals.lww.com
Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …