Genome-wide association study identifies African-specific susceptibility loci in African Americans with inflammatory bowel disease

SR Brant, DT Okou, CL Simpson, DJ Cutler… - Gastroenterology, 2017 - Elsevier
Background & Aims The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and
Crohn's disease (CD) cause significant morbidity and are increasing in prevalence among …

Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort

RY Cordero, JB Cordero, AB Stiemke… - Human molecular …, 2023 - academic.oup.com
Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal disorder with
major phenotypes: ulcerative colitis (UC) and Crohn's disease (CD). Multiple studies have …

Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans

C Huang, T Haritunians, DT Okou, DJ Cutler, ME Zwick… - Gastroenterology, 2015 - Elsevier
Background & Aims Inflammatory bowel disease (IBD) has familial aggregation in African
Americans (AAs), but little is known about the molecular genetic susceptibility. Mapping …

Genetic characteristics of inflammatory bowel disease in a Japanese population

Y Fuyuno, K Yamazaki, A Takahashi, M Esaki… - Journal of …, 2016 - Springer
Background Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of
inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies …

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

JZ Liu, S Van Sommeren, H Huang, SC Ng, R Alberts… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Identification of three novel susceptibility loci for inflammatory bowel disease in Koreans in an extended genome-wide association study

S Jung, BD Ye, HS Lee, J Baek, G Kim… - Journal of Crohn's …, 2021 - academic.oup.com
Abstract Background and Aims Genome-wide association studies [GWAS] of inflammatory
bowel disease [IBD] in multiple populations have identified over 240 susceptibility loci. We …

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

Z Liu, R Liu, H Gao, S Jung, X Gao, R Sun, X Liu… - Nature …, 2023 - nature.com
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …

An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians

G Juyal, P Prasad, S Senapati, V Midha, A Sood… - PloS one, 2011 - journals.plos.org
Genome-Wide Association studies (GWAS) of both Crohn's Disease (CD) and Ulcerative
Colitis (UC) have unearthed over 40 risk conferring variants. Recently, a meta-analysis on …

[PDF][PDF] Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

HK Somineni, S Nagpal, S Venkateswaran… - The American Journal of …, 2021 - cell.com
Whether or not populations diverge with respect to the genetic contribution to risk of specific
complex diseases is relevant to understanding the evolution of susceptibility and origins of …

Identification of loci at 1q21 and 16q23 that affect susceptibility to inflammatory bowel disease in Koreans

SK Yang, M Hong, H Oh, HQ Low, S Jung, S Ahn… - Gastroenterology, 2016 - Elsevier
Recent genome-wide association studies have identified more than 200 regions that affect
susceptibility to inflammatory bowel disease (IBD). However, identified common variants …