High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: a soft clustering analysis
Background Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-
causing pathways are incompletely understood and (2) subclassification may improve …
causing pathways are incompletely understood and (2) subclassification may improve …
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach
OBJECTIVE Recent genome-wide association studies have resulted in a dramatic increase
in our knowledge of the genetic loci involved in type 2 diabetes. In a complementary …
in our knowledge of the genetic loci involved in type 2 diabetes. In a complementary …
Systems biology approach reveals genome to phenome correlation in type 2 diabetes
Genome-wide association studies (GWASs) have discovered association of several loci with
Type 2 diabetes (T2D), a common complex disease characterized by impaired insulin …
Type 2 diabetes (T2D), a common complex disease characterized by impaired insulin …
[HTML][HTML] Multi-ancestry genome-wide study in> 2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes. To characterise the genetic contribution to these processes …
pathophysiological processes. To characterise the genetic contribution to these processes …
Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy
MI McCarthy, E Zeggini - Trends in pharmacological sciences, 2007 - cell.com
Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental
factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 …
factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 …
Type 2 diabetes: genetic data sharing to advance complex disease research
J Flannick, JC Florez - Nature Reviews Genetics, 2016 - nature.com
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …
experimental characterization have for years formed a paradigm for identifying genes or …
Insights into the genetic basis of type 2 diabetes
N Kato - Journal of diabetes investigation, 2013 - Wiley Online Library
Type 2 diabetes is one of the most common complex diseases, of which considerable efforts
have been made to unravel the pathophysiological mechanisms. Recently, large‐scale …
have been made to unravel the pathophysiological mechanisms. Recently, large‐scale …
[HTML][HTML] Genetics of type 1 diabetes: what's next?
F Pociot, B Akolkar, P Concannon, HA Erlich, C Julier… - Diabetes, 2010 - ncbi.nlm.nih.gov
The discovery of the association between HLA in the major histocompatibility complex
(MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested …
(MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested …
Genetic architecture of type 2 diabetes
K Hara, N Shojima, J Hosoe, T Kadowaki - Biochemical and biophysical …, 2014 - Elsevier
Genome-wide association studies (GWAS) have identified over 70 loci associated with type
2 diabetes (T2D). Most genetic variants associated with T2D are common variants with …
2 diabetes (T2D). Most genetic variants associated with T2D are common variants with …