GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
[PDF][PDF] Leveraging polygenic functional enrichment to improve GWAS power
Functional genomics data has the potential to increase GWAS power by identifying SNPs
that have a higher prior probability of association. Here, we introduce a method that …
that have a higher prior probability of association. Here, we introduce a method that …
[HTML][HTML] Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
The identification of genes and regulatory elements underlying the associations discovered
by GWAS is essential to understanding the aetiology of complex traits (including diseases) …
by GWAS is essential to understanding the aetiology of complex traits (including diseases) …
[HTML][HTML] 15 years of genome-wide association studies and no signs of slowing down
RJF Loos - Nature communications, 2020 - nature.com
Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …
[HTML][HTML] GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies
To facilitate broad and convenient integrative visualization of and access to GWAS data, we
have created the GWAS Central resource (http://www. gwascentral. org). This database …
have created the GWAS Central resource (http://www. gwascentral. org). This database …
An atlas of genetic associations in UK Biobank
O Canela-Xandri, K Rawlik, A Tenesa - Nature genetics, 2018 - nature.com
Genome-wide association studies (GWAS) have identified many loci contributing to variation
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …
[HTML][HTML] Exome sequencing and analysis of 454,787 UK Biobank participants
JD Backman, AH Li, A Marcketta, D Sun, J Mbatchou… - Nature, 2021 - nature.com
A major goal in human genetics is to use natural variation to understand the phenotypic
consequences of altering each protein-coding gene in the genome. Here we used exome …
consequences of altering each protein-coding gene in the genome. Here we used exome …
[PDF][PDF] 15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery
Most signals in genome-wide association studies (GWAS) of complex traits point to
noncoding genetic variants with putative gene regulatory effects. However, currently …
noncoding genetic variants with putative gene regulatory effects. However, currently …
[HTML][HTML] From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases
E Cano-Gamez, G Trynka - Frontiers in genetics, 2020 - frontiersin.org
Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …
associated with complex traits. These associations could reveal the molecular mechanisms …