Modest effect sizes have limited the clinical applicability of genetic associations with
rheumatic diseases. Genetic risk scores (GRSs) have emerged as a promising solution to …

The two major goals of common disease genetics research have been dissection of the
aetiopathogenesis of common diseases, and the development of genetic predictors or …

Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait
compared to a matched population. For many rheumatic diseases PRS have been …

Background Recent discoveries of risk alleles have made it possible to define genetic risk
profiles for patients with rheumatoid arthritis (RA). This study examined whether a …

Background There is currently great interest in the incorporation of genetic susceptibility loci
into screening models to identify individuals at high risk of disease. Here, we present the first …

Background Rheumatoid arthritis (RA) shares genetic variants with other autoimmune
conditions, but existing studies test the association between RA variants with a pre-defined …

Objectives To evaluate selection methods among published single-nucleotide
polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) …

The study of rheumatic diseases draws on many genome-scale technologies. Box 1 defines
relevant terms that will be used in this discussion. Genome-wide association studies …

As the field of genetics research advances, our understanding of complex diseases and their
underlying mechanisms has expanded exponentially. Genomewide association studies …

Nearly 110 susceptibility loci for rheumatoid arthritis (RA) have been identified in population-
based genetic association studies; however, these variants account for only a small …