Intestinal epithelial cell (IEC) regulation of barrier function and mucosal homeostasis
enables the establishment of a harmonious gut microenvironment. However, host-derived …

G protein-coupled receptor 35 (GPR35), a receptor for lysophosphatidic acid, is highly
expressed in the gastrointestinal tract. Recently, GPR35 has been implicated in the onset of …

Abstract Background and Aims During active inflammation, intraluminal intestinal pH is
decreased in patients with inflammatory bowel disease [IBD]. Acidic pH may play a role in …

Simple Summary Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's
disease, is a debilitating condition with chronic inflammation in the digestive tract. Patients …

At mucosal sites such as the intestine, the immune system launches robust immunity against
invading pathogens while maintaining a state of tolerance to commensal flora and ingested …

The dysregulation of the intestinal epithelial barrier significantly contributes to the
inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate …

The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial
roles in the regulation of intestinal homeostasis by controlling microbiota. Gut microbiota has …

Extracellular acidification occurs in inflamed tissue and the tumor microenvironment;
however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking …

Inflammatory bowel disease (IBD) is characterized by chronic mucosal inflammation of the
gastrointestinal tract and is associated with extracellular acidification of mucosal tissue …

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35
(GPR35) are associated with increased risk of inflammatory bowel disease. However, the …