Relationship of major depressive disorder and schizophrenia polygenic risk scores to suicide: a comparison between European and Asian ancestry populations

I Otsuka, H Galfalvy, J Guo, M Akiyama… - Archives of suicide …, 2024 - Taylor & Francis
Psychiatric diagnosis rates in suicide decedents appear higher in European ancestry
populations compared with East Asians. Shared genetic components exist between major …

Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits

I Otsuka, H Galfalvy, J Guo, M Akiyama… - Psychological …, 2023 - cambridge.org
Background Suicidal behavior is moderately heritable and a consequence of a combination
of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders …

[HTML][HTML] Insights into suicide and depression

NH Kalin - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
The suffering, anguish, and psychological trauma that loved ones endure when losing a
family member to suicide is devastating, and for most people, unimaginable. As mental …

Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression

MB Stein, S Jain, L Campbell‐Sills… - American Journal of …, 2021 - Wiley Online Library
Suicide is a major public health problem. The contribution of common genetic variants for
major depressive disorder (MDD) independent of personal and parental history of MDD has …

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

N Mullins, TB Bigdeli, AD Børglum… - American journal of …, 2019 - Am Psychiatric Assoc
Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is …

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome‐wide association and polygenic scoring study

N Mullins, N Perroud, R Uher, AW Butler… - American Journal of …, 2014 - Wiley Online Library
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is
independent of other psychiatric disorders. Genome‐wide association studies (GWAS) on …

European Depression Polygenic Risk Score Predicts Suicide Behavior in Mexicans

G Martínez-Levy, M Renteria… - Biological …, 2021 - biologicalpsychiatryjournal.com
Background Depression is frequently linked to suicide behaviors (ideation, plan, and
attempt). To date, the association between the Major Depressive Disorder Polygenic Risk …

Genetic correlations between suicide attempts and psychiatric and intermediate phenotypes adjusting for mental disorders

D Fujikane, K Ohi, A Kuramitsu, K Takai… - Psychological …, 2024 - cambridge.org
BackgroundSuicide attempts are a moderately heritable trait, and genetic correlations with
psychiatric and related intermediate phenotypes have been reported. However, as several …

[HTML][HTML] Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

N Mullins, TB Bigdeli, AD Børglum… - The American journal …, 2019 - ncbi.nlm.nih.gov
Objective: Over 90% of suicide attempters have a psychiatric diagnosis, however twin and
family studies suggest that the genetic etiology of suicide attempt (SA) is partially distinct …

[HTML][HTML] Genetic associations with suicide attempt severity and genetic overlap with major depression

DF Levey, R Polimanti, Z Cheng, H Zhou… - Translational …, 2019 - nature.com
Abstract In 2015,~ 800,000 people died by suicide worldwide. For every death by suicide
there are as many as 25 suicide attempts, which can result in serious injury even when not …