DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA
variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) …

Identification of functional, noncoding elements that regulate transcription in the context of
complex genomes is a major goal of modern biology. Localization of functionality to specific …

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation
in all organisms. Genetic variation in regulatory regions has been connected with diseases …

Interactions between eukaryotic transcription factors and their cognate DNA binding sites
form fundamental networks within cells that control critical steps during development and …

Dynamic protein binding to DNA elements regulates genome function and cell fate. Although
methods for mapping in vivo protein-DNA interactions are becoming crucial for every aspect …

The function of human regulatory regions depends exquisitely on their local genomic
environment and on cellular context, complicating experimental analysis of common disease …

The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through …

The orchestrated binding of transcriptional activators and repressors to specific DNA
sequences in the context of chromatin defines the regulatory program of eukaryotic …

Transcriptional control in large genomes often requires looping interactions between distal
DNA elements, such as enhancers and target promoters. Current chromosome conformation …

Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with
sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In …