[HTML][HTML] Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes

J Qiao, Y Wu, S Zhang, Y Xu, J Zhang, P Zeng, T Wang - BMC genomics, 2023 - Springer
Background Genome-wide association studies (GWASs) have identified many single-
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …

Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations

H Lu, T Wang, J Zhang, S Zhang, S Huang, P Zeng - Human Genetics, 2021 - Springer
Genome-wide association studies (GWASs) have successfully identified a large amount of
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …

[HTML][HTML] Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?

AM Casto, MW Feldman - PLoS genetics, 2011 - journals.plos.org
Genome-wide association studies (GWAS) have identified more than 2,000 trait-SNP
associations, and the number continues to increase. GWAS have focused on traits with …

[HTML][HTML] Similarity and diversity of genetic architecture for complex traits between East Asian and European populations

J Zhang, S Zhang, J Qiao, T Wang, P Zeng - BMC genomics, 2023 - Springer
Background Genome-wide association studies have detected a large number of single-
nucleotide polymorphisms (SNPs) associated with complex traits in diverse ancestral …

Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

AI Campos, S Namba, SC Lin, K Nam, J Sidorenko… - Nature Genetics, 2023 - nature.com
Genome-wide association studies (GWASs) have been mostly conducted in populations of
European ancestry, which currently limits the transferability of their findings to other …

[HTML][HTML] A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese

P Qin, Z Li, W Jin, D Lu, H Lou, J Shen, L Jin… - European Journal of …, 2014 - nature.com
Population stratification acts as a confounding factor in genetic association studies and may
lead to false-positive or false-negative results. Previous studies have analyzed the genetic …

[HTML][HTML] An overview of strategies for detecting genotype-phenotype associations across ancestrally diverse populations

I Simonin-Wilmer, P Orozco-del-Pino, DT Bishop… - Frontiers in …, 2021 - frontiersin.org
Genome-wide association studies (GWAS) have been very successful at identifying genetic
variants influencing a large number of traits. Although the great majority of these studies …

[HTML][HTML] Quantifying genetic heterogeneity between continental populations for human height and body mass index

J Guo, A Bakshi, Y Wang, L Jiang, L Yengo… - Scientific reports, 2021 - nature.com
Genome-wide association studies (GWAS) in samples of European ancestry have identified
thousands of genetic variants associated with complex traits in humans. However, it remains …

[HTML][HTML] Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing

J Qiao, Z Shao, Y Wu, P Zeng, T Wang - Journal of Translational Medicine, 2022 - Springer
Background Detecting trans-ethnic common associated genetic loci can offer important
insights into shared genetic components underlying complex diseases/traits across diverse …

[HTML][HTML] All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

AJ Schork, WK Thompson, P Pham, A Torkamani… - PLoS …, 2013 - journals.plos.org
Recent results indicate that genome-wide association studies (GWAS) have the potential to
explain much of the heritability of common complex phenotypes, but methods are lacking to …