Background Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been
associated with many diseases in observational studies; however, the causality of …

Background: Sex hormone-binding globulin (SHBG) is a circulating glycoprotein and a
regulator of sex hormone levels, which has been shown to influence various traits and …

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and
biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has …

Sex differences have been shown in laboratory biomarkers; however, the extent to which
this is due to genetics is unknown. In this study, we infer sex-specific genetic parameters …

Background Testosterone plays a key role in women, but the associations of serum
testosterone level with gynecological disorders risk are inconclusive in observational …

Objective Epidemiological and clinical studies have highlighted important roles for sex
hormones in the regulation of fat distribution and systemic metabolism. We investigated the …

Background Testosterone levels are linked with diverse characteristics of human health, yet,
whether these associations reflect correlation or causation remains debated. Here, we …

Testosterone concentrations in men are associated with cardiovascular morbidity,
osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of …

Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory
mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified …

Objective Concentrations of circulating sex hormones have been associated with a variety of
diseases in women and are strongly influenced by menopausal status. We investigated the …