A large-scale genome-wide association study meta-analysis of cannabis use disorder
Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …
(estimated twin and family heritability about 50–70%) and is associated with negative …
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …
debated. Shared underlying genetic risk is one potential explanation. We investigated the …
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Cannabis use is a heritable trait that has been associated with adverse mental health
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
Genome-wide association study of cannabis dependence severity, novel risk variants, and shared genetic risks
Importance Cannabis dependence (CAD) is a serious problem worldwide and is of growing
importance in the United States because cannabis is increasingly available legally …
importance in the United States because cannabis is increasingly available legally …
Genetic association between schizophrenia and cannabis use
Background and aim Previous studies have shown a relationship between schizophrenia
and cannabis use. As both traits are substantially heritable, a shared genetic liability could …
and cannabis use. As both traits are substantially heritable, a shared genetic liability could …
Genetic predisposition to schizophrenia associated with increased use of cannabis
Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the
legalization and control of use, investigating its health risks has become a pressing area of …
legalization and control of use, investigating its health risks has become a pressing area of …
The relationship between cannabis and schizophrenia: a genetically informed perspective
Abstract Background and Aims While epidemiological studies support a role for heavy, high‐
potency cannabis use on first‐episode psychosis, genetic models of causation suggest …
potency cannabis use on first‐episode psychosis, genetic models of causation suggest …
Cannabis use and risk of schizophrenia: a Mendelian randomization study
Cannabis use is observationally associated with an increased risk of schizophrenia, but
whether the relationship is causal is not known. Using a genetic approach, we took 10 …
whether the relationship is causal is not known. Using a genetic approach, we took 10 …
Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank
Cannabis is known to produce acute, transient psychotic-like experiences. However, it is
unclear whether cannabis disproportionately increases the risk of specific types of psychotic …
unclear whether cannabis disproportionately increases the risk of specific types of psychotic …
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
Cannabis is the most widely produced and consumed illicit psychoactive substance
worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence …
worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence …