Admixed populations, with their unique and diverse genetic backgrounds, are often
underrepresented in genetic studies. This oversight not only limits our understanding but …

Leveraging local ancestry and haplotype information in genome-wide association studies
and downstream analyses can improve the utility of genomics for individuals from diverse …

Admixed populations constitute a large portion of global human genetic diversity, yet they
are often left out of genomics analyses. This exclusion is problematic, as it leads to …

Understanding the genetic causes of human diseases and traits has long been of interest in
the scientific community. However, the large majority of research in this area has been …

The large volume of research findings submitted to the GWAS catalog in the last decade is a
clear indication of the exponential progress of these studies and association approaches …

Individuals of European descent have historically been the focus of genetic studies and
possess relatively homogenous genomes. As a result, analytical methods have been …

Objective The performances of popular genome-wide association study (GWAS) models
have not been examined yet in a consistent manner under the scenario of genetic …

Next-generation sequencing technologies now make it possible to sequence and genotype
hundreds of thousands of genetic markers across the human genome. Selection of …

Admixture refers to the mixing of genetic ancestry from different populations. Admixture is
important for genomic medicine because it can affect how an individual responds to certain …

Linear mixed models are effective tools to identify genetic loci contributing to phenotypic
variation while handling confounding due to population structure and cryptic relatedness …