[HTML][HTML] Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …
[HTML][HTML] Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
[HTML][HTML] Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …
[HTML][HTML] Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis
SE Graham, JB Nielsen, M Zawistowski, W Zhou… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is a growing health burden currently affecting 10–15% of
adults worldwide. Estimated glomerular filtration rate (eGFR) as a marker of kidney function …
adults worldwide. Estimated glomerular filtration rate (eGFR) as a marker of kidney function …
[HTML][HTML] Genome-wide association study of kidney function decline in individuals of European descent
Genome-wide association studies (GWASs) have identified multiple loci associated with
cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time …
cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time …
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
[HTML][HTML] Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals
KJ Stanzick, Y Li, P Schlosser, M Gorski… - Nature …, 2021 - nature.com
Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …
function are promising targets for functional studies, but prioritizing variants and genes is …
Genome-wide association of CKD progression: the chronic renal insufficiency cohort study
The rate of decline of renal function varies significantly among individuals with CKD. To
understand better the contribution of genetics to CKD progression, we performed a genome …
understand better the contribution of genetics to CKD progression, we performed a genome …
[HTML][HTML] A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND)
F Thameem, RP Igo Jr, BI Freedman, C Langefeld… - PloS one, 2013 - journals.plos.org
Objective Estimated glomerular filtration rate (eGFR), a measure of kidney function, is
heritable, suggesting that genes influence renal function. Genes that influence eGFR have …
heritable, suggesting that genes influence renal function. Genes that influence eGFR have …
[HTML][HTML] Association of eGFR-related loci identified by GWAS with incident CKD and ESRD
Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD)
and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome …
and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome …