Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

Background Genome-wide association studies have identified multiple risk variants for
psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders …

The successful discovery of genes that cause rare monogenic disorders has dominated our
understanding of the genetic basis of neurodegenerative disease. The emergence of robust …

Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

Recent human genetic studies have consistently shown that mutations in the same gene or
same genomic region can increase the risk of a broad range of complex neuropsychiatric …

Revealing the underlying pathomechanisms of neurological and psychiatric disorders,
searching for new biomarkers, and developing novel therapeutics all require translational …

Leveraging high-dimensional molecular datasets can help us develop mechanistic insight
into associations between genetic variants and complex traits. In this study, we integrated …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …