Inflammatory bowel disease (IBD), a general term encompassing Crohn's disease (CD) and
ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease …

Abstract Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol
to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the …

Cholesterol, as an important component in mammalian cells, is efficient for viral entry,
replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized …

Background & Aims Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-
hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti …

Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD],
frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; …

Background High-fat diet (HFD) is closely associated with the increased prevalence of
inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid …

Obesity is a major risk factor for several diseases including diabetes, heart disease, and
some forms of cancer and due to its rapidly increasing prevalence it has become one of the …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …