Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

DS Palmer, DP Howrigan, SB Chapman, R Adolfsson… - Nature …, 2022 - nature.com
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

L Jones, K Gordon-Smith, A Perry - Nature Genetics, 2021 - eprints.worc.ac.uk
Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …

Genome-wide association study reveals two new risk loci for bipolar disorder

TW Mühleisen, M Leber, TG Schulze… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Genome-wide association study identifies 30 loci associated with bipolar disorder

EA Stahl, G Breen, AJ Forstner, A McQuillin, S Ripke… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …

Exome sequencing of familial bipolar disorder

FS Goes, M Pirooznia, JS Parla, M Kramer… - JAMA …, 2016 - jamanetwork.com
Importance Complex disorders, such as bipolar disorder (BD), likely result from the influence
of both common and rare susceptibility alleles. While common variation has been widely …

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

DM Ruderfer, AH Fanous, S Ripke, A McQuillin… - Molecular …, 2014 - nature.com
Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities.
Recent studies have demonstrated a large overlap of genetic risk loci between these …

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

MAR Ferreira, MC O'Donovan, YA Meng, IR Jones… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387
cases and 6,209 controls and identified a region of strong association (rs10994336, P= 9.1× …

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Nature genetics, 2011 - nature.com
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …

Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement

AE Baum, M Hamshere, E Green, S Cichon… - Molecular …, 2008 - nature.com
Two genome-wide association studies (GWAS) of bipolar disorder have been published to
date, one in this journal 1 and one in Nature. 2 Cursory consideration of the top findings in …