More than 800 million people in the world suffer from chronic kidney disease (CKD).
Genome-wide association studies (GWAS) have identified hundreds of loci where genetic …

Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …

Chronic kidney disease (CKD) is common, affecting about 10% of the general population,
and causing significant morbidity and mortality. Apart from the risk conferred by traditional …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

Recent studies suggest that deletion of the core clock gene Bmal1 in the kidney has a
significant influence on renal physiological functions. However, the role of renal Bmal1 in …

The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

Background Genetic variants identified in genome-wide association studies (GWAS) are
often not specific enough to reveal complex underlying physiology. By integrating RNA-seq …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Many common genetic variants identified by genome-wide association studies for complex
traits map to genes previously linked to rare inherited Mendelian disorders. A systematic …

Kidney diseases constitute a serious public health burden worldwide, with substantial
associated morbidity and mortality. The role of a genetic contribution to kidney disease is …