Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

Variance-component methods that estimate the aggregate contribution of large sets of
variants to the heritability of complex traits have yielded important insights into the genetic …

Although genetic correlations between complex traits provide valuable insights into
epidemiological and etiological studies, a precise quantification of which genomic regions …

Despite the success of large-scale genome-wide association studies (GWASs) on complex
traits, our understanding of their genetic architecture is far from complete. Jointly modeling …

Non-additive genetic variance for complex traits is traditionally estimated from data on
relatives. It is notoriously difficult to estimate without bias in non-laboratory species …

For complex disease genetics research in human populations, remarkable progress has
been made in recent times with the publication of a number of genome-wide association …

There are many known examples of multiple semi-independent associations at individual
loci; such associations might arise either because of true allelic heterogeneity or because of …

The omnigenic model was proposed as a framework to understand the highly polygenic
architecture of complex traits revealed by genome-wide association studies (GWASs). I …

Recent successes in genome-wide association studies (GWASs) make it possible to
address important questions about the genetic architecture of complex traits, such as allele …

Despite the growing number of genome-wide association studies (GWASs), it remains
unclear to what extent gene-by-gene and gene-by-environment interactions influence …